Drug interactions
Clemastine + Marijuana
Severity: Moderate
Clemastine and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis causes sedation and psychomotor impairment, which can be increased by sedating antihistamines like clemastine. Cannabis may also add to dizziness and tachycardia.
What this interaction means in plain words
Clemastine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Advise avoiding cannabis while taking clemastine and not driving or operating machinery if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Marijuana?
MediHelp rates the interaction as moderate. Clemastine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis causes sedation and psychomotor impairment, which can be increased by sedating antihistamines like clemastine. Cannabis may also add to dizziness and tachycardia.
How serious is the interaction between Clemastine and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding cannabis while taking clemastine and not driving or operating machinery if drowsy.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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