Drug interactions
Clemastine + Pimozide
Severity: Moderate
Clemastine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating first-generation antihistamine with anticholinergic activity. Combined with pimozide, additive drowsiness and anticholinergic effects may occur.
What this interaction means in plain words
Clemastine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Use a non-sedating antihistamine where possible. Otherwise monitor for sedation and anticholinergic effects and advise caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Pimozide?
MediHelp rates the interaction as moderate. Clemastine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating first-generation antihistamine with anticholinergic activity. Combined with pimozide, additive drowsiness and anticholinergic effects may occur.
How serious is the interaction between Clemastine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-sedating antihistamine where possible. Otherwise monitor for sedation and anticholinergic effects and advise caution with driving.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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