Drug interactions
Clemastine + Protriptyline
Severity: Moderate
Clemastine and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sedative and anticholinergic properties. Together they can increase drowsiness, impair psychomotor performance, and worsen dry mouth, constipation, urinary retention and confusion, especially in older adults.
What this interaction means in plain words
Clemastine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Counsel patients about driving and alcohol; in older patients or those with glaucoma or urinary retention, prefer a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Protriptyline?
MediHelp rates the interaction as moderate. Clemastine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sedative and anticholinergic properties. Together they can increase drowsiness, impair psychomotor performance, and worsen dry mouth, constipation, urinary retention and confusion, especially in older adults.
How serious is the interaction between Clemastine and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about driving and alcohol; in older patients or those with glaucoma or urinary retention, prefer a non-sedating antihistamine.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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