Drug interactions
Clemastine + Quazepam
Severity: Moderate
Clemastine and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A sedating antihistamine added to a benzodiazepine hypnotic increases drowsiness and impairs next-day alertness, coordination and memory. Falls and accidents are a particular concern in older patients.
What this interaction means in plain words
Clemastine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Avoid driving and alcohol; consider a non-sedating antihistamine or a reduced benzodiazepine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Quazepam?
MediHelp rates the interaction as moderate. Clemastine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A sedating antihistamine added to a benzodiazepine hypnotic increases drowsiness and impairs next-day alertness, coordination and memory. Falls and accidents are a particular concern in older patients.
How serious is the interaction between Clemastine and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid driving and alcohol; consider a non-sedating antihistamine or a reduced benzodiazepine dose.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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