Drug interactions
Clemastine + Scullcap
Severity: Minor
Clemastine and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap is a herbal product traditionally used for its calming effect and may add to the sedation of clemastine. Evidence is limited, but increased drowsiness and impaired alertness are plausible.
What this interaction means in plain words
Clemastine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; the mechanism of the herb is not well established.
What to do
Advise patients to watch for excess drowsiness and avoid driving if affected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Scullcap?
MediHelp rates the interaction as minor. Clemastine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap is a herbal product traditionally used for its calming effect and may add to the sedation of clemastine. Evidence is limited, but increased drowsiness and impaired alertness are plausible.
How serious is the interaction between Clemastine and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for excess drowsiness and avoid driving if affected.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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