Drug interactions
Clemastine + Thiothixene
Severity: Moderate
Clemastine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have anticholinergic activity. Together they can increase drowsiness, confusion, dry mouth, constipation and urinary retention.
What this interaction means in plain words
Clemastine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor sedation and anticholinergic effects, especially in older adults; prefer a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Thiothixene?
MediHelp rates the interaction as moderate. Clemastine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have anticholinergic activity. Together they can increase drowsiness, confusion, dry mouth, constipation and urinary retention.
How serious is the interaction between Clemastine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and anticholinergic effects, especially in older adults; prefer a non-sedating antihistamine.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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