Drug interactions
Clemastine + Triclofos
Severity: Moderate
Clemastine and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic whose active metabolite is trichloroethanol, and it adds to the sedation of clemastine. This can cause marked drowsiness and impaired coordination, especially in children and older patients.
What this interaction means in plain words
Clemastine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Avoid combined use where possible; if needed, monitor sedation and avoid other depressants and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Triclofos?
MediHelp rates the interaction as moderate. Clemastine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic whose active metabolite is trichloroethanol, and it adds to the sedation of clemastine. This can cause marked drowsiness and impaired coordination, especially in children and older patients.
How serious is the interaction between Clemastine and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible; if needed, monitor sedation and avoid other depressants and driving.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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