Drug interactions
Clemastine + Yohimbine
Severity: Minor
Clemastine and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is sedating whereas yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects, so they may partly oppose each other. The net result is unpredictable and no well-documented clinical harm exists.
What this interaction means in plain words
Clemastine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no pharmacokinetic mechanism is established.
What to do
No routine change is needed. Do not rely on yohimbine to counteract antihistamine sedation, and monitor for anxiety, tachycardia or excess drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Yohimbine?
MediHelp rates the interaction as minor. Clemastine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clemastine is sedating whereas yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects, so they may partly oppose each other. The net result is unpredictable and no well-documented clinical harm exists.
How serious is the interaction between Clemastine and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Do not rely on yohimbine to counteract antihistamine sedation, and monitor for anxiety, tachycardia or excess drowsiness.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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