Drug interactions
Clindamycin + Microbiota
Severity: Major
Clindamycin and Microbiota: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral fecal microbiota products contain live bacterial spores meant to re-establish the gut flora after Clostridioides difficile infection. Antibacterial agents active against these organisms can suppress engraftment and lower efficacy. Clindamycin has broad anaerobic activity and is itself a major risk factor for C. difficile.
What this interaction means in plain words
Clindamycin and Microbiota can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Antibacterial activity against the administered live bacterial spores and the resulting flora impairs engraftment and colonization.
What to do
Complete any antibiotic course before starting the microbiota product, observing the interval in the product labeling. Avoid starting clindamycin during or soon after microbiota therapy unless clearly necessary.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clindamycin
Frequently asked questions
Can I take Clindamycin with Microbiota?
MediHelp rates the interaction as major. Clindamycin and Microbiota can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral fecal microbiota products contain live bacterial spores meant to re-establish the gut flora after Clostridioides difficile infection. Antibacterial agents active against these organisms can suppress engraftment and lower efficacy. Clindamycin has broad anaerobic activity and is itself a major risk factor for C. difficile.
How serious is the interaction between Clindamycin and Microbiota?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete any antibiotic course before starting the microbiota product, observing the interval in the product labeling. Avoid starting clindamycin during or soon after microbiota therapy unless clearly necessary.
What other medicines interact with Clindamycin?
MediHelp also lists interactions of Clindamycin with, for example, Atracurium, Cisatracurium, Pancuronium. The full list is on the Clindamycin page.
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