Drug interactions
Clonidine + Doxazosin
Severity: Moderate
Clonidine and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents reduce sympathetic vascular tone and can lower blood pressure additively, leading to hypotension and dizziness. Clonidine may also cause bradycardia or conduction problems in susceptible patients.
What this interaction means in plain words
Clonidine and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Doxazosin belongs to Genitourinary.
Why it happens
Additive sympatholytic effects from central alpha-2 agonism and peripheral alpha-1 blockade.
What to do
Monitor blood pressure and heart rate, and avoid abrupt clonidine withdrawal because of rebound hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Doxazosin?
MediHelp rates the interaction as moderate. Clonidine and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents reduce sympathetic vascular tone and can lower blood pressure additively, leading to hypotension and dizziness. Clonidine may also cause bradycardia or conduction problems in susceptible patients.
How serious is the interaction between Clonidine and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and avoid abrupt clonidine withdrawal because of rebound hypertension.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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