Drug interactions
Clonidine + Droperidol
Severity: Moderate
Clonidine and Droperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, and droperidol adds sedation and QT prolongation risk. Together they may cause hypotension and drowsiness.
What this interaction means in plain words
Clonidine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from central alpha-2 agonism and alpha-adrenergic blockade, plus additive sedation.
What to do
Monitor blood pressure and ECG during and after droperidol administration. Treat hypotension with fluids and reduce doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Droperidol?
MediHelp rates the interaction as moderate. Clonidine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, and droperidol adds sedation and QT prolongation risk. Together they may cause hypotension and drowsiness.
How serious is the interaction between Clonidine and Droperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ECG during and after droperidol administration. Treat hypotension with fluids and reduce doses if needed.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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