Drug interactions
Clonidine + Esketamine intranasal
Severity: Moderate
Clonidine and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine can cause sedation and transient increases in blood pressure, whereas clonidine causes sedation and lowers blood pressure. Together they may produce excessive drowsiness and unpredictable blood pressure changes during and after the esketamine session.
What this interaction means in plain words
Clonidine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and opposing hemodynamic effects of NMDA antagonism with sympathetic stimulation versus central alpha-2 agonism.
What to do
Monitor blood pressure before and after esketamine dosing and observe the patient for sedation for the full post-dose period. Do not stop clonidine abruptly because of this combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Esketamine intranasal?
MediHelp rates the interaction as moderate. Clonidine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine can cause sedation and transient increases in blood pressure, whereas clonidine causes sedation and lowers blood pressure. Together they may produce excessive drowsiness and unpredictable blood pressure changes during and after the esketamine session.
How serious is the interaction between Clonidine and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and after esketamine dosing and observe the patient for sedation for the full post-dose period. Do not stop clonidine abruptly because of this combination.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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