Drug interactions
Clonidine + Flurazepam
Severity: Moderate
Clonidine and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and their combination can increase drowsiness, dizziness, impaired coordination and hypotension. Flurazepam has long-acting active metabolites, so effects can persist, especially in older adults.
What this interaction means in plain words
Clonidine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation by the benzodiazepine and central alpha-2 agonist sedation and hypotension from clonidine.
What to do
Use the lowest effective doses and monitor for next-day sedation and orthostatic hypotension. Consider a shorter-acting alternative in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Flurazepam?
MediHelp rates the interaction as moderate. Clonidine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and their combination can increase drowsiness, dizziness, impaired coordination and hypotension. Flurazepam has long-acting active metabolites, so effects can persist, especially in older adults.
How serious is the interaction between Clonidine and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for next-day sedation and orthostatic hypotension. Consider a shorter-acting alternative in older patients.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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