Drug interactions
Clonidine + Pimozide
Severity: Moderate
Clonidine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide can cause sedation and some hypotension, which may add to clonidine's effects, causing dizziness and drowsiness. Clonidine-related bradycardia may also be unfavorable alongside pimozide, which prolongs the QT interval.
What this interaction means in plain words
Clonidine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Pimozide belongs to Central Nervous System.
Why it happens
Additive hypotensive and CNS depressant effects; bradycardia from clonidine may increase risk of QT-related arrhythmia with pimozide.
What to do
Monitor blood pressure, heart rate and sedation, and obtain an ECG if bradycardia or symptoms occur. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Clonidine with Pimozide?
MediHelp rates the interaction as moderate. Clonidine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide can cause sedation and some hypotension, which may add to clonidine's effects, causing dizziness and drowsiness. Clonidine-related bradycardia may also be unfavorable alongside pimozide, which prolongs the QT interval.
How serious is the interaction between Clonidine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation, and obtain an ECG if bradycardia or symptoms occur. Correct potassium and magnesium abnormalities.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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