Drug interactions
Clonidine + Quazepam
Severity: Moderate
Clonidine and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine has sedative and blood pressure lowering effects, and quazepam is a long-acting benzodiazepine hypnotic. Used together they can increase drowsiness, dizziness, psychomotor impairment and hypotension, raising the risk of falls, especially in older adults.
What this interaction means in plain words
Clonidine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression through central alpha-2 agonism and GABA-A potentiation.
What to do
Start quazepam at the lowest dose and monitor for excessive sedation and orthostatic hypotension. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Quazepam?
MediHelp rates the interaction as moderate. Clonidine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine has sedative and blood pressure lowering effects, and quazepam is a long-acting benzodiazepine hypnotic. Used together they can increase drowsiness, dizziness, psychomotor impairment and hypotension, raising the risk of falls, especially in older adults.
How serious is the interaction between Clonidine and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start quazepam at the lowest dose and monitor for excessive sedation and orthostatic hypotension. Counsel patients to avoid driving and alcohol.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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