Drug interactions
Clonidine + Telotristat ethyl
Severity: Minor
Clonidine and Telotristat ethyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat ethyl can induce CYP3A4 and lower exposure to sensitive substrates. Clonidine depends on CYP3A4 only minimally, so a meaningful loss of antihypertensive effect is unlikely.
What this interaction means in plain words
Clonidine and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 induction by telotristat may slightly increase clearance of clonidine.
What to do
No empirical dose change is required; check blood pressure after starting telotristat and adjust clonidine if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Telotristat ethyl?
MediHelp rates the interaction as minor. Clonidine and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telotristat ethyl can induce CYP3A4 and lower exposure to sensitive substrates. Clonidine depends on CYP3A4 only minimally, so a meaningful loss of antihypertensive effect is unlikely.
How serious is the interaction between Clonidine and Telotristat ethyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required; check blood pressure after starting telotristat and adjust clonidine if control worsens.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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