Drug interactions
Clonidine + Thiothixene
Severity: Moderate
Clonidine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene, an antipsychotic with alpha-1 blocking activity, can cause orthostatic hypotension and sedation, which may add to the blood pressure lowering and sedation of clonidine. Confusion may occur in susceptible patients.
What this interaction means in plain words
Clonidine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive and sedative effects from alpha-1 adrenergic blockade and central alpha-2 agonism.
What to do
Monitor supine and standing blood pressure and mental status when combining. Titrate doses gradually and reduce either drug if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Thiothixene?
MediHelp rates the interaction as moderate. Clonidine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene, an antipsychotic with alpha-1 blocking activity, can cause orthostatic hypotension and sedation, which may add to the blood pressure lowering and sedation of clonidine. Confusion may occur in susceptible patients.
How serious is the interaction between Clonidine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure and mental status when combining. Titrate doses gradually and reduce either drug if symptomatic hypotension occurs.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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