Drug interactions
Clozapine + Deferiprone
Severity: Contraindicated
Clozapine and Deferiprone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause severe neutropenia and agranulocytosis, and using them together may compound the risk. Deferiprone labeling advises against its use with other drugs known to cause neutropenia.
What this interaction means in plain words
Clozapine and Deferiprone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clozapine belongs to Central Nervous System; Deferiprone belongs to Miscellaneous.
Why it happens
Additive bone marrow suppression and risk of agranulocytosis.
What to do
Avoid concurrent use and choose an alternative iron chelator or antipsychotic. If unavoidable, monitor the absolute neutrophil count very frequently and stop at the first sign of neutropenia.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clozapine
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
- Adrenaline-articaine + Clozapine Major
Other interactions of Deferiprone
Frequently asked questions
Can I take Clozapine with Deferiprone?
MediHelp rates the interaction as contraindicated. Clozapine and Deferiprone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can cause severe neutropenia and agranulocytosis, and using them together may compound the risk. Deferiprone labeling advises against its use with other drugs known to cause neutropenia.
How serious is the interaction between Clozapine and Deferiprone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative iron chelator or antipsychotic. If unavoidable, monitor the absolute neutrophil count very frequently and stop at the first sign of neutropenia.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Irinotecan, Pimozide, Thioridazine. The full list is on the Clozapine page.
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