Drug interactions
Collagenase clostridium histolyticum + Heparin
Severity: Moderate
Collagenase clostridium histolyticum and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Collagenase injections into Dupuytren's cords or Peyronie's plaques commonly cause bruising and hematoma at the site, and anticoagulants may worsen this. Serious bleeding is uncommon, but the risk is higher with full anticoagulation.
What this interaction means in plain words
Collagenase clostridium histolyticum and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Heparin impairs clotting, increasing local bleeding and ecchymosis from collagenase-induced tissue disruption.
What to do
Where clinically possible, delay collagenase injection while therapeutic anticoagulation is in place. If the injection is needed, inspect the site for hematoma and bleeding afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Collagenase clostridium histolyticum with Heparin?
MediHelp rates the interaction as moderate. Collagenase clostridium histolyticum and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Collagenase injections into Dupuytren's cords or Peyronie's plaques commonly cause bruising and hematoma at the site, and anticoagulants may worsen this. Serious bleeding is uncommon, but the risk is higher with full anticoagulation.
How serious is the interaction between Collagenase clostridium histolyticum and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where clinically possible, delay collagenase injection while therapeutic anticoagulation is in place. If the injection is needed, inspect the site for hematoma and bleeding afterward.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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