Drug interactions
Concizumab + Factor ix
Severity: Major
Concizumab and Factor ix: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concizumab reduces bleeding by inhibiting tissue factor pathway inhibitor, so added factor IX at high or frequent doses can increase thrombotic risk. Thromboembolic events have been reported with concomitant breakthrough-bleed treatment.
What this interaction means in plain words
Concizumab and Factor ix can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Concizumab belongs to Miscellaneous; Factor ix belongs to Cardiovascular.
Why it happens
Additive procoagulant effects of TFPI inhibition and exogenous factor replacement.
What to do
Use the lowest approved factor IX dose that achieves hemostasis for breakthrough bleeds. Monitor for signs of thrombosis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Concizumab
- Concizumab + Factor viii Major
Other interactions of Factor ix
Frequently asked questions
Can I take Concizumab with Factor ix?
MediHelp rates the interaction as major. Concizumab and Factor ix can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concizumab reduces bleeding by inhibiting tissue factor pathway inhibitor, so added factor IX at high or frequent doses can increase thrombotic risk. Thromboembolic events have been reported with concomitant breakthrough-bleed treatment.
How serious is the interaction between Concizumab and Factor ix?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest approved factor IX dose that achieves hemostasis for breakthrough bleeds. Monitor for signs of thrombosis.
What other medicines interact with Concizumab?
MediHelp also lists interactions of Concizumab with, for example, Factor viii. The full list is on the Concizumab page.
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