Drug interactions
Conivaptan + Diltiazem
Severity: Moderate
Conivaptan and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and its levels may also be raised by diltiazem. Exposure to both drugs may increase, with a risk of hypotension, excessive aquaresis and overly rapid sodium correction.
What this interaction means in plain words
Conivaptan and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bidirectional CYP3A4 inhibition reduces the metabolism of both drugs.
What to do
Monitor blood pressure, heart rate and serum sodium closely, with sodium rise kept within safe limits. Reduce or stop conivaptan if excessive correction occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Conivaptan with Diltiazem?
MediHelp rates the interaction as moderate. Conivaptan and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and its levels may also be raised by diltiazem. Exposure to both drugs may increase, with a risk of hypotension, excessive aquaresis and overly rapid sodium correction.
How serious is the interaction between Conivaptan and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum sodium closely, with sodium rise kept within safe limits. Reduce or stop conivaptan if excessive correction occurs.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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