Drug interactions
Conivaptan + Ethinyl estradiol-levonorgestrel
Severity: Moderate
Conivaptan and Ethinyl estradiol-levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and can increase exposure to CYP3A4 substrates such as ethinyl estradiol and levonorgestrel. This may increase estrogen and progestin related adverse effects, though the effect with short-term intravenous conivaptan use is likely modest.
What this interaction means in plain words
Conivaptan and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ethinyl estradiol and levonorgestrel.
What to do
Monitor for estrogenic adverse effects such as nausea, breast tenderness, hypertension and thrombosis signs during the short course of conivaptan. Consider whether the contraceptive needs to be continued if the patient has other thrombotic risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Conivaptan with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as moderate. Conivaptan and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and can increase exposure to CYP3A4 substrates such as ethinyl estradiol and levonorgestrel. This may increase estrogen and progestin related adverse effects, though the effect with short-term intravenous conivaptan use is likely modest.
How serious is the interaction between Conivaptan and Ethinyl estradiol-levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects such as nausea, breast tenderness, hypertension and thrombosis signs during the short course of conivaptan. Consider whether the contraceptive needs to be continued if the patient has other thrombotic risk factors.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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