Drug interactions
Conivaptan + Griseofulvin
Severity: Moderate
Conivaptan and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 substrate, and griseofulvin may reduce its exposure. This could weaken correction of hyponatremia.
What this interaction means in plain words
Conivaptan and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by griseofulvin increases conivaptan metabolism.
What to do
Monitor serum sodium frequently during conivaptan infusion and adjust therapy if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Conivaptan with Griseofulvin?
MediHelp rates the interaction as moderate. Conivaptan and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 substrate, and griseofulvin may reduce its exposure. This could weaken correction of hyponatremia.
How serious is the interaction between Conivaptan and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium frequently during conivaptan infusion and adjust therapy if the response is inadequate.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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