Drug interactions
Conivaptan + Metronidazole
Severity: Minor
Conivaptan and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 substrate, but metronidazole is only a weak inhibitor, so a clinically important rise in conivaptan levels is unlikely.
What this interaction means in plain words
Conivaptan and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by metronidazole may marginally reduce conivaptan clearance.
What to do
No adjustment is needed; monitor serum sodium as usual to avoid overly rapid correction.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Conivaptan with Metronidazole?
MediHelp rates the interaction as minor. Conivaptan and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan is a CYP3A4 substrate, but metronidazole is only a weak inhibitor, so a clinically important rise in conivaptan levels is unlikely.
How serious is the interaction between Conivaptan and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor serum sodium as usual to avoid overly rapid correction.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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