Drug interactions
Conivaptan + Ulipristal
Severity: Moderate
Conivaptan and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may raise ulipristal exposure. Increased exposure could increase adverse effects, though ulipristal is given as a single dose.
What this interaction means in plain words
Conivaptan and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, reducing ulipristal metabolism.
What to do
Consider an alternative emergency contraceptive if possible. If ulipristal is used, counsel the patient on possible increased side effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Conivaptan with Ulipristal?
MediHelp rates the interaction as moderate. Conivaptan and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may raise ulipristal exposure. Increased exposure could increase adverse effects, though ulipristal is given as a single dose.
How serious is the interaction between Conivaptan and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative emergency contraceptive if possible. If ulipristal is used, counsel the patient on possible increased side effects.
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