Drug interactions
Conivaptan + Zaleplon
Severity: Minor
Conivaptan and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor and may raise zaleplon exposure somewhat. Because zaleplon is mainly cleared by aldehyde oxidase, the increase is likely modest.
What this interaction means in plain words
Conivaptan and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition reduces the secondary oxidative metabolism of zaleplon.
What to do
No routine adjustment is needed; monitor for excess sedation while conivaptan is being given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Conivaptan with Zaleplon?
MediHelp rates the interaction as minor. Conivaptan and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan is a strong CYP3A4 inhibitor and may raise zaleplon exposure somewhat. Because zaleplon is mainly cleared by aldehyde oxidase, the increase is likely modest.
How serious is the interaction between Conivaptan and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for excess sedation while conivaptan is being given.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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