Drug interactions
Contrast media + Tenofovir disoproxil
Severity: Moderate
Contrast media and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast can cause acute kidney injury, and tenofovir disoproxil is also associated with renal tubular toxicity. Together they may raise the risk of renal impairment, and reduced renal function can increase tenofovir exposure.
What this interaction means in plain words
Contrast media and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from contrast-induced tubular injury and tenofovir proximal tubular toxicity.
What to do
Ensure adequate hydration and monitor serum creatinine and electrolytes after contrast. Adjust tenofovir dosing if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Contrast media with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Contrast media and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast can cause acute kidney injury, and tenofovir disoproxil is also associated with renal tubular toxicity. Together they may raise the risk of renal impairment, and reduced renal function can increase tenofovir exposure.
How serious is the interaction between Contrast media and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor serum creatinine and electrolytes after contrast. Adjust tenofovir dosing if renal function declines.
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