Drug interactions
Copanlisib + Diltiazem
Severity: Moderate
Copanlisib and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Copanlisib is metabolized mainly by CYP3A4, and diltiazem is a moderate inhibitor. Raised copanlisib exposure may increase hyperglycemia, hypertension, infection and other toxicities.
What this interaction means in plain words
Copanlisib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diltiazem inhibits CYP3A4 and reduces copanlisib clearance.
What to do
Monitor blood glucose, blood pressure and signs of toxicity. Consider reducing the copanlisib dose as labeled when a moderate CYP3A inhibitor is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Copanlisib with Diltiazem?
MediHelp rates the interaction as moderate. Copanlisib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Copanlisib is metabolized mainly by CYP3A4, and diltiazem is a moderate inhibitor. Raised copanlisib exposure may increase hyperglycemia, hypertension, infection and other toxicities.
How serious is the interaction between Copanlisib and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure and signs of toxicity. Consider reducing the copanlisib dose as labeled when a moderate CYP3A inhibitor is required.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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