Drug interactions
Copanlisib + Isoniazid
Severity: Moderate
Copanlisib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may inhibit CYP3A4 and increase copanlisib exposure, which could worsen hyperglycemia, hypertension, infections and pneumonitis.
What this interaction means in plain words
Copanlisib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Isoniazid inhibits CYP3A4, the main metabolic route of copanlisib.
What to do
Monitor blood glucose, blood pressure and signs of infection or pneumonitis. Reduce the copanlisib dose per labeling if a stronger CYP3A inhibitor effect is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Copanlisib with Isoniazid?
MediHelp rates the interaction as moderate. Copanlisib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may inhibit CYP3A4 and increase copanlisib exposure, which could worsen hyperglycemia, hypertension, infections and pneumonitis.
How serious is the interaction between Copanlisib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure and signs of infection or pneumonitis. Reduce the copanlisib dose per labeling if a stronger CYP3A inhibitor effect is suspected.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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