Drug interactions
Cortisone + Deferasirox
Severity: Moderate
Cortisone and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone is metabolized in part by CYP3A4, so deferasirox may lower corticosteroid exposure through weak induction. Systemic corticosteroids also add GI ulceration risk with deferasirox.
What this interaction means in plain words
Cortisone and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 induction by deferasirox, plus additive GI mucosal toxicity.
What to do
Monitor clinical response to cortisone and watch for GI bleeding. Consider gastroprotection if therapy is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Frequently asked questions
Can I take Cortisone with Deferasirox?
MediHelp rates the interaction as moderate. Cortisone and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone is metabolized in part by CYP3A4, so deferasirox may lower corticosteroid exposure through weak induction. Systemic corticosteroids also add GI ulceration risk with deferasirox.
How serious is the interaction between Cortisone and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to cortisone and watch for GI bleeding. Consider gastroprotection if therapy is prolonged.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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