Drug interactions
Cortisone + Diltiazem
Severity: Minor
Cortisone and Diltiazem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may slightly raise exposure to corticosteroids cleared by CYP3A4. Cortisone is a prodrug converted to cortisol, and meaningful effects are expected mainly with prolonged high doses.
What this interaction means in plain words
Cortisone and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition by diltiazem may reduce corticosteroid clearance.
What to do
No routine adjustment is needed. Monitor for corticosteroid excess such as fluid retention, hyperglycemia and hypertension during long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Cortisone with Diltiazem?
MediHelp rates the interaction as minor. Cortisone and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diltiazem may slightly raise exposure to corticosteroids cleared by CYP3A4. Cortisone is a prodrug converted to cortisol, and meaningful effects are expected mainly with prolonged high doses.
How serious is the interaction between Cortisone and Diltiazem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for corticosteroid excess such as fluid retention, hyperglycemia and hypertension during long-term use.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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