Drug interactions
Cortisone + Fenoprofen
Severity: Moderate
Cortisone and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and NSAIDs together considerably raise the risk of gastric and duodenal ulceration and gastrointestinal bleeding compared with either alone. The risk is greater in older patients, with prolonged use or at higher doses.
What this interaction means in plain words
Cortisone and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs reduce protective prostaglandin synthesis in the gastric mucosa while corticosteroids impair mucosal healing, producing additive ulcer risk.
What to do
Use the lowest effective doses for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Monitor for dyspepsia, melena and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Cortisone with Fenoprofen?
MediHelp rates the interaction as moderate. Cortisone and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and NSAIDs together considerably raise the risk of gastric and duodenal ulceration and gastrointestinal bleeding compared with either alone. The risk is greater in older patients, with prolonged use or at higher doses.
How serious is the interaction between Cortisone and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Monitor for dyspepsia, melena and anemia.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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