Drug interactions
Cortisone + Glibenclamide
Severity: Moderate
Cortisone and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids like cortisone increase hepatic glucose output and cause insulin resistance, raising blood glucose. This can reduce glyburide's effectiveness, and glucose may rise noticeably during prolonged or high-dose use.
What this interaction means in plain words
Cortisone and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-induced insulin resistance and increased gluconeogenesis oppose glyburide's effect.
What to do
Monitor blood glucose when corticosteroids are started, and increase the glyburide dose or add insulin if needed. Reduce the antidiabetic dose again as the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Cortisone with Glibenclamide?
MediHelp rates the interaction as moderate. Cortisone and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids like cortisone increase hepatic glucose output and cause insulin resistance, raising blood glucose. This can reduce glyburide's effectiveness, and glucose may rise noticeably during prolonged or high-dose use.
How serious is the interaction between Cortisone and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when corticosteroids are started, and increase the glyburide dose or add insulin if needed. Reduce the antidiabetic dose again as the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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