Drug interactions
Cortisone + Griseofulvin
Severity: Moderate
Cortisone and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may accelerate corticosteroid metabolism and reduce cortisone effect. This matters most in patients with adrenal insufficiency, where reduced cover could be harmful.
What this interaction means in plain words
Cortisone and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by griseofulvin increases corticosteroid clearance.
What to do
Monitor for signs of inadequate glucocorticoid effect and increase the cortisone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Cortisone with Griseofulvin?
MediHelp rates the interaction as moderate. Cortisone and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may accelerate corticosteroid metabolism and reduce cortisone effect. This matters most in patients with adrenal insufficiency, where reduced cover could be harmful.
How serious is the interaction between Cortisone and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of inadequate glucocorticoid effect and increase the cortisone dose if needed.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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