Drug interactions
Cortisone + Hepatitis A vaccine inactivated
Severity: Minor
Cortisone and Hepatitis A vaccine inactivated: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose or prolonged corticosteroid therapy may reduce the antibody response to inactivated hepatitis A vaccine. It is not a contraindication because the vaccine is non-replicating.
What this interaction means in plain words
Cortisone and Hepatitis A vaccine inactivated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucocorticoid suppression of lymphocyte function may modestly blunt vaccine immunogenicity.
What to do
Vaccinate as indicated without delay; consider checking antibody response in patients on sustained high-dose steroids.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Cortisone with Hepatitis A vaccine inactivated?
MediHelp rates the interaction as minor. Cortisone and Hepatitis A vaccine inactivated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High-dose or prolonged corticosteroid therapy may reduce the antibody response to inactivated hepatitis A vaccine. It is not a contraindication because the vaccine is non-replicating.
How serious is the interaction between Cortisone and Hepatitis A vaccine inactivated?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as indicated without delay; consider checking antibody response in patients on sustained high-dose steroids.
What other medicines interact with Hepatitis A vaccine inactivated?
MediHelp also lists interactions of Hepatitis A vaccine inactivated with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Hepatitis A vaccine inactivated page.
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