Drug interactions
Cortisone + Hydrochlorothiazide-olmesartan
Severity: Moderate
Cortisone and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids with mineralocorticoid activity promote renal potassium loss, which adds to the hypokalemia caused by hydrochlorothiazide. Low potassium may increase the risk of arrhythmias and muscle weakness, and fluid retention may weaken blood pressure control.
What this interaction means in plain words
Cortisone and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting from corticosteroid mineralocorticoid effects and thiazide diuresis.
What to do
Monitor serum potassium and blood pressure, particularly with prolonged or high-dose corticosteroid use. Supplement potassium or adjust therapy if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Cortisone with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Cortisone and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids with mineralocorticoid activity promote renal potassium loss, which adds to the hypokalemia caused by hydrochlorothiazide. Low potassium may increase the risk of arrhythmias and muscle weakness, and fluid retention may weaken blood pressure control.
How serious is the interaction between Cortisone and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, particularly with prolonged or high-dose corticosteroid use. Supplement potassium or adjust therapy if hypokalemia develops.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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