Drug interactions
Cortisone + Indapamide
Severity: Moderate
Cortisone and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone has mineralocorticoid activity that promotes renal potassium loss. Combined with indapamide, hypokalemia can be enhanced, which increases arrhythmia risk especially in patients with heart disease or on digoxin.
What this interaction means in plain words
Cortisone and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting from diuretic action and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium and magnesium regularly and supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Cortisone with Indapamide?
MediHelp rates the interaction as moderate. Cortisone and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone has mineralocorticoid activity that promotes renal potassium loss. Combined with indapamide, hypokalemia can be enhanced, which increases arrhythmia risk especially in patients with heart disease or on digoxin.
How serious is the interaction between Cortisone and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and supplement potassium if needed.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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