Drug interactions
Cortisone + Insulin lispro
Severity: Moderate
Cortisone and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone raises blood glucose and can reduce the effectiveness of insulin, leading to hyperglycemia and higher insulin requirements. The effect is more pronounced with higher or prolonged dosing.
What this interaction means in plain words
Cortisone and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and peripheral insulin resistance, opposing insulin action.
What to do
Monitor blood glucose closely during corticosteroid therapy and increase insulin lispro doses as needed. Reduce insulin again when the steroid is tapered or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Frequently asked questions
Can I take Cortisone with Insulin lispro?
MediHelp rates the interaction as moderate. Cortisone and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone raises blood glucose and can reduce the effectiveness of insulin, leading to hyperglycemia and higher insulin requirements. The effect is more pronounced with higher or prolonged dosing.
How serious is the interaction between Cortisone and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during corticosteroid therapy and increase insulin lispro doses as needed. Reduce insulin again when the steroid is tapered or stopped.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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