Drug interactions
Cortisone + Isoniazid
Severity: Minor
Cortisone and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may weakly inhibit CYP3A4, which could modestly raise corticosteroid exposure. Cortisone is a prodrug converted to cortisol, and the clinical effect is probably small. Corticosteroids may also alter isoniazid acetylation.
What this interaction means in plain words
Cortisone and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition by isoniazid reducing corticosteroid clearance.
What to do
No routine adjustment needed. Monitor for corticosteroid adverse effects with prolonged therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Cortisone with Isoniazid?
MediHelp rates the interaction as minor. Cortisone and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid may weakly inhibit CYP3A4, which could modestly raise corticosteroid exposure. Cortisone is a prodrug converted to cortisol, and the clinical effect is probably small. Corticosteroids may also alter isoniazid acetylation.
How serious is the interaction between Cortisone and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed. Monitor for corticosteroid adverse effects with prolonged therapy.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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