Drug interactions
Cortisone + Metformin-sitagliptin
Severity: Moderate
Cortisone and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as cortisone raise blood glucose and can reduce the effectiveness of antidiabetic drugs. Hyperglycemia may be significant with higher doses or prolonged use.
What this interaction means in plain words
Cortisone and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroids increase hepatic gluconeogenesis and insulin resistance, opposing the glucose-lowering effect.
What to do
Monitor glucose closely during corticosteroid therapy and increase the antidiabetic regimen if needed. Reassess doses when the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Cortisone with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Cortisone and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as cortisone raise blood glucose and can reduce the effectiveness of antidiabetic drugs. Hyperglycemia may be significant with higher doses or prolonged use.
How serious is the interaction between Cortisone and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely during corticosteroid therapy and increase the antidiabetic regimen if needed. Reassess doses when the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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