Drug interactions
Cosyntropin + Hydrochlorothiazide-olmesartan
Severity: Minor
Cosyntropin and Hydrochlorothiazide-olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cosyntropin stimulates adrenal cortisol and some mineralocorticoid release, which can promote potassium loss. With a thiazide diuretic, potassium and electrolyte depletion may be modestly increased, but this is mostly relevant with repeated dosing.
What this interaction means in plain words
Cosyntropin and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cosyntropin belongs to Musculoskeletal; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from adrenal steroid stimulation and thiazide diuresis.
What to do
No routine action is needed for a single diagnostic dose; check serum potassium if cosyntropin is given repeatedly or the patient is already hypokalemic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Cosyntropin
Frequently asked questions
Can I take Cosyntropin with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as minor. Cosyntropin and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cosyntropin stimulates adrenal cortisol and some mineralocorticoid release, which can promote potassium loss. With a thiazide diuretic, potassium and electrolyte depletion may be modestly increased, but this is mostly relevant with repeated dosing.
How serious is the interaction between Cosyntropin and Hydrochlorothiazide-olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for a single diagnostic dose; check serum potassium if cosyntropin is given repeatedly or the patient is already hypokalemic.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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