Drug interactions
Creatine + Ketorolac
Severity: Minor
Creatine and Ketorolac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Creatine supplements can raise serum creatinine and have been theorized to stress the kidney at high doses. Ketorolac can reduce renal perfusion, so concurrent use might add to renal risk, although clinical evidence is lacking.
What this interaction means in plain words
Creatine and Ketorolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive renal stress; NSAID prostaglandin inhibition combined with creatine-related changes in renal markers.
What to do
Monitor renal function if used together over a prolonged period, and consider that creatine may raise serum creatinine without true injury.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Creatine with Ketorolac?
MediHelp rates the interaction as minor. Creatine and Ketorolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Creatine supplements can raise serum creatinine and have been theorized to stress the kidney at high doses. Ketorolac can reduce renal perfusion, so concurrent use might add to renal risk, although clinical evidence is lacking.
How serious is the interaction between Creatine and Ketorolac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function if used together over a prolonged period, and consider that creatine may raise serum creatinine without true injury.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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