Drug interactions
Cyclopenthiazide + Epinephrine
Severity: Moderate
Cyclopenthiazide and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine moves potassium into cells, while cyclopenthiazide promotes renal potassium excretion. The combination can result in additive hypokalemia and increased arrhythmia risk.
What this interaction means in plain words
Cyclopenthiazide and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta2-mediated potassium shift into cells combined with thiazide-induced renal potassium wasting.
What to do
Monitor serum potassium and magnesium and correct deficits when systemic epinephrine is used. Monitor ECG in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Cyclopenthiazide with Epinephrine?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine moves potassium into cells, while cyclopenthiazide promotes renal potassium excretion. The combination can result in additive hypokalemia and increased arrhythmia risk.
How serious is the interaction between Cyclopenthiazide and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits when systemic epinephrine is used. Monitor ECG in patients with cardiac disease.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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