Drug interactions
Cyclopenthiazide + Fenoprofen
Severity: Moderate
Cyclopenthiazide and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effect of thiazide diuretics through sodium and water retention. They also add to renal risk, especially in volume-depleted or elderly patients.
What this interaction means in plain words
Cyclopenthiazide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and natriuresis, opposing thiazide action.
What to do
Monitor blood pressure, fluid status, renal function and electrolytes; ensure adequate hydration and adjust the diuretic if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Cyclopenthiazide with Fenoprofen?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and antihypertensive effect of thiazide diuretics through sodium and water retention. They also add to renal risk, especially in volume-depleted or elderly patients.
How serious is the interaction between Cyclopenthiazide and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, renal function and electrolytes; ensure adequate hydration and adjust the diuretic if control is lost.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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