Drug interactions
Cyclopenthiazide + Indapamide
Severity: Moderate
Cyclopenthiazide and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two thiazide-type diuretics together add little antihypertensive benefit and increase the risk of hypokalemia, hyponatremia and dehydration.
What this interaction means in plain words
Cyclopenthiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Both inhibit the distal tubular sodium-chloride cotransporter, producing additive electrolyte loss.
What to do
Avoid duplicate thiazide therapy and use a single agent. If both have been given, check electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Cyclopenthiazide with Indapamide?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two thiazide-type diuretics together add little antihypertensive benefit and increase the risk of hypokalemia, hyponatremia and dehydration.
How serious is the interaction between Cyclopenthiazide and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate thiazide therapy and use a single agent. If both have been given, check electrolytes and renal function.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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