Drug interactions
Cyclopenthiazide + Metformin-sitagliptin
Severity: Minor
Cyclopenthiazide and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide, a thiazide diuretic, may increase blood glucose and weaken the effect of antidiabetic treatment. The effect is usually modest at low doses.
What this interaction means in plain words
Cyclopenthiazide and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-induced hypokalemia and impaired insulin secretion and glucose utilization antagonize antidiabetic effects.
What to do
Monitor glucose and potassium after starting or increasing the thiazide, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Cyclopenthiazide with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Cyclopenthiazide and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclopenthiazide, a thiazide diuretic, may increase blood glucose and weaken the effect of antidiabetic treatment. The effect is usually modest at low doses.
How serious is the interaction between Cyclopenthiazide and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and potassium after starting or increasing the thiazide, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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