Drug interactions
Cyclopenthiazide + Pirbuterol
Severity: Moderate
Cyclopenthiazide and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide is a thiazide diuretic that increases renal potassium excretion, and pirbuterol can lower serum potassium through cellular uptake. Together they may cause additive hypokalemia and raise the risk of arrhythmias in susceptible patients.
What this interaction means in plain words
Cyclopenthiazide and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from thiazide renal potassium loss and beta-2 mediated intracellular shift.
What to do
Monitor serum potassium and magnesium and correct deficits. Take extra care in patients with cardiac disease or on other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclopenthiazide and Pirbuterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Frequently asked questions
Can I take Cyclopenthiazide with Pirbuterol?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclopenthiazide is a thiazide diuretic that increases renal potassium excretion, and pirbuterol can lower serum potassium through cellular uptake. Together they may cause additive hypokalemia and raise the risk of arrhythmias in susceptible patients.
How serious is the interaction between Cyclopenthiazide and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits. Take extra care in patients with cardiac disease or on other QT-prolonging drugs.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
