Drug interactions
Cyclopenthiazide + Telmisartan-amlodipine
Severity: Moderate
Cyclopenthiazide and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide is a thiazide diuretic that adds to the blood pressure lowering of telmisartan-amlodipine. The ARB tends to retain potassium while the thiazide wastes it, so the net effect on potassium varies between patients, and volume depletion may impair renal function.
What this interaction means in plain words
Cyclopenthiazide and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effects, with opposing effects on potassium: ARB-mediated reduced aldosterone effect versus thiazide-induced renal potassium loss.
What to do
Monitor blood pressure, serum potassium and creatinine after starting or adjusting either drug. Watch for symptomatic hypotension, especially in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Frequently asked questions
Can I take Cyclopenthiazide with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclopenthiazide is a thiazide diuretic that adds to the blood pressure lowering of telmisartan-amlodipine. The ARB tends to retain potassium while the thiazide wastes it, so the net effect on potassium varies between patients, and volume depletion may impair renal function.
How serious is the interaction between Cyclopenthiazide and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after starting or adjusting either drug. Watch for symptomatic hypotension, especially in volume-depleted patients.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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