Drug interactions
Cyclosporine + Glimepiride-pioglitazone
Severity: Moderate
Cyclosporine and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can alter the effect of sulfonylureas and may cause hyperglycemia on its own. Cyclosporine may also raise glimepiride levels, and its concentration can vary with the interaction, though the evidence is limited.
What this interaction means in plain words
Cyclosporine and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine is a CYP3A4 and transporter inhibitor and can impair insulin secretion, but the mechanism of the interaction with glimepiride is not well established.
What to do
Monitor blood glucose closely and adjust the antidiabetic regimen as required. Check cyclosporine trough levels if the antidiabetic regimen is changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Frequently asked questions
Can I take Cyclosporine with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Cyclosporine and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can alter the effect of sulfonylureas and may cause hyperglycemia on its own. Cyclosporine may also raise glimepiride levels, and its concentration can vary with the interaction, though the evidence is limited.
How serious is the interaction between Cyclosporine and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and adjust the antidiabetic regimen as required. Check cyclosporine trough levels if the antidiabetic regimen is changed.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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