Drug interactions
Cyclosporine + Griseofulvin
Severity: Major
Cyclosporine and Griseofulvin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin has been associated with reduced cyclosporine concentrations in case reports. Subtherapeutic levels can lead to graft rejection in transplant recipients.
What this interaction means in plain words
Cyclosporine and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 by griseofulvin increases cyclosporine metabolism.
What to do
Monitor cyclosporine trough levels closely when starting or stopping griseofulvin and adjust the dose accordingly; consider an alternative antifungal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Cyclosporine with Griseofulvin?
MediHelp rates the interaction as major. Cyclosporine and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin has been associated with reduced cyclosporine concentrations in case reports. Subtherapeutic levels can lead to graft rejection in transplant recipients.
How serious is the interaction between Cyclosporine and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels closely when starting or stopping griseofulvin and adjust the dose accordingly; consider an alternative antifungal.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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